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Integrins
Hierarchy: | ∟ ∟ ∟ ∟ ∟ ∟ Integrins 13 coordinate concepts8 subordinate concepts∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ |
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Annotation: | prefer specifics
X |
History note: | Glycoproteins (1966-1987) | Membrane Glycoproteins (1988-1989) | Receptors, Endogenous Substances (1973-1989) | Receptors, Immunologic (1980-1989)X |
historyNote*: | 90
X |
publicMeSHNote*: | 90
X |
Scope note: | A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.
X |
activeMeSHYear*: | |
dateCreated*: | 1989-07-07X |
dateEstablished*: | 1990-01-01X |
dateRevised*: | 2005-07-18X |
recordAuthorizer*: | agsX |
recordMaintainer*: | agsX |
recordOriginator*: | RLSX |
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Labels and equivalent concepts: | Integriinit (fi) XIntegrinas (es) ενσωματίνες (el) Integrine (de) integriny (cs) |
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