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Tetrahydrofolate Dehydrogenase
Hierarchy: | ∟ ∟ ∟ ∟ ∟ Tetrahydrofolate Dehydrogenase 11 coordinate concepts1 subordinate concept∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ |
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historyNote*: | 66; DIHYDROFOLATE DEHYDROGENASE was heading 1966-88
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onlineNote*: | use TETRAHYDROFOLATE DEHYDROGENASE to search DIHYDROFOLATE DEHYDROGENASE 1966-88
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publicMeSHNote*: | 66; DIHYDROFOLATE DEHYDROGENASE was heading 1966-88
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Scope note: | An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.
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activeMeSHYear*: | |
dateCreated*: | 1999-01-01X |
dateEstablished*: | 1966-01-01X |
dateRevised*: | 2005-06-30X |
recordAuthorizer*: | sjnX |
recordMaintainer*: | jmpX |
recordOriginator*: | NLMX |
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Labels and equivalent concepts: | Tetrahydrofolaattidehydrogenaasi (fi) XFolic Acid Reductase (en, replaced) Dihydrofolate Reductase (en, replaced) Dihydrofolate Dehydrogenase (en, replaced) Tetrahidrofolato Deshidrogenasa (es) δεϋδρογονάση τετραϋδροφολικού (el) Tetrahydrofolat-Dehydrogenase (de) tetrahydrofolátdehydrogenasa (cs) Dihidrofolato Deshidrogenasa (es, replaced) Dihidrofolato Reductasa (es, replaced) Reductasa del Ácido Fólico (es, replaced) Dihydrofolatreductase (de, replaced) Folsäurereductase (de, replaced) Dihydrofolatdehydrogenase (de, replaced) |
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