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Methylenetetrahydrofolate Dehydrogenase (NADP)
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Annotation: | do not confuse with METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NAD+)
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historyNote*: | 2004(1975);
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publicMeSHNote*: | 2004; see METHYLENETETRAHYDROFOLATE DEHYDROGENASE 1991-2003; see OXIDOREDUCTASES 1975-1990
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Scope note: | An NADP-dependent oxidoreductase that catalyses the conversion of 5,10-methyleneterahydrofolate to 5,10-methenyl-tetrahydrofolate. In higher eukaryotes a trifunctional enzyme exists with additional METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE and FORMATE-TETRAHYDROFOLATE LIGASE activity. The enzyme plays an important role in the synthesis of 5-methyltetrahydrofolate, the methyl donor for the VITAMIN B12-dependent remethylation of HOMOCYSTEINE to METHIONINE via METHIONINE SYNTHETASE.
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activeMeSHYear*: | 2007X |
dateCreated*: | 1974-11-19X |
dateEstablished*: | 1991-01-01X |
dateRevised*: | 2006-07-05X |
recordAuthorizer*: | sjnX |
recordMaintainer*: | agsX |
recordOriginator*: | NLMX |
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Labels and equivalent concepts: | Metyleenitetrahydrofolaattidehydrogenaasi (NADP) (fi) XMethylenetetrahydrofolate Dehydrogenase (NADP+) (en, replaced) Methylenetetrahydrofolate Dehydrogenase (en, replaced) Metilenotetrahidrofolato Deshidrogenasa (NADP) (es) δεϋδρογονάση μεθυλενοτετραϋδροφολικού (el) Methylentetrahydrofolat-Dehydrogenase (de) methylentetrahydrofolátdehydrogenasa (NADP) (cs) Metilenotetrahidrofolato Deshidrogenasa (NADP+) (es, replaced) |
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