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Lovastatin
Hierarchy: | ∟ ∟ ∟ ∟ ∟ ∟ ∟ Lovastatin 17 coordinate concepts1 subordinate concept∟ ∟ ∟ ∟ Lovastatin 17 coordinate concepts1 subordinate conceptX |
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Annotation: | /biosyn permitted if by fungus
X |
History note: | Anticholesteremic Agents (1966-1987) | Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors (1977-1987) | Naphthalenes (1966-1987)X |
historyNote*: | 88; for MONACOLIN K use LOVASTATIN (NM) 1980-98
X |
publicMeSHNote*: | 88; MONACOLIN K was indexed under NAPHTHALENES 1981-98 & ANTIBIOTICS 1980
X |
Scope note: | A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.
X |
activeMeSHYear*: | 2007X |
dateCreated*: | 1987-05-04X |
dateEstablished*: | 1988-01-01X |
dateRevised*: | 2006-07-05X |
recordAuthorizer*: | sjnX |
recordMaintainer*: | ssbX |
recordOriginator*: | RLSX |
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Labels and equivalent concepts: | Lovastatiini (fi) XMonacolin K (en, replaced) Mevinolin (en, replaced) 6-Methylcompactin (en, replaced) Lovastatina (es) λοβαστατίνη (el) Mevinolina (es, replaced) Mevinolin (de, replaced) |
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