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Insulin
Hierarchy: | ∟ ∟ ∟ ∟ ∟ ∟ Insulin 1 coordinate concept3 subordinate concepts∟ ∟ ∟ ∟ ∟ Insulin 1 coordinate concept3 subordinate concepts∟ ∟ ∟ ∟ ∟ ∟ Insulin 1 coordinate concept3 subordinate conceptsX |
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Annotation: | /blood: consider also HYPERINSULINEMIA (excessively high blood insulin levels) but do not confuse with HYPERINSULINISM (excessive secretion of insulin by pancreas); /immunology: consider also INSULIN ANTIBODIES; precursor = PROINSULIN; INSULIN INFUSION SYSTEMS is available
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Scope note: | A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
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activeMeSHYear*: | 2007X |
dateCreated*: | 1999-01-01X |
dateRevised*: | 2006-07-05X |
recordAuthorizer*: | sjnX |
recordMaintainer*: | lktX |
recordOriginator*: | NLMX |
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Labels and equivalent concepts: | Insuliini (fi) XInsulin, Regular (en, replaced) Insulina (es) ινσουλίνη (el) |
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