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Cytochrome P-450 Enzyme System
Hierarchy: | ∟ ∟ ∟ ∟ ∟ Cytochrome P-450 Enzyme System 22 coordinate concepts5 subordinate concepts∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ Cytochrome P-450 Enzyme System 22 coordinate concepts5 subordinate concepts∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ Cytochrome P-450 Enzyme System 22 coordinate concepts5 subordinate concepts∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ ∟ |
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Annotation: | GEN or unspecified; prefer specific cytochrome P-450's; /biosyn /physiol permitted
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History note: | Cytochromes (1966-1972)X |
historyNote*: | 73; CYTOCHROME P-450 OXYGENASE was NM 1977-96
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publicMeSHNote*: | 73; CYTOCHROME P-450 OXYGENASE was indexed under CYTOCHROME P-450 & OXYGENASES 1977-96
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Scope note: | A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
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activeMeSHYear*: | |
dateCreated*: | 1999-01-01X |
dateEstablished*: | 1973-01-01X |
dateRevised*: | 2004-07-07X |
recordAuthorizer*: | sjnX |
recordMaintainer*: | ssbX |
recordOriginator*: | NLMX |
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Labels and equivalent concepts: | Sytokromi P-450 -entsyymijärjestelmä (fi) XCytochrome P450 (en, replaced) Cytochrome P-450-Dependent Monooxygenase (en, replaced) Cytochrome P-450 (en, replaced) Sistema Enzimático del Citocromo P-450 (es) κυτόχρωμα P-450 (el) Cytochrom-P-450-Enzym-System (de) systém (enzymů) cytochromů P-450 (cs) Citocromo P-450 (es, replaced) Citocromo P-450-Monooxigenasa Dependiente (es, replaced) Zytochrom P-450 (de, replaced) Zytochrom P-450-abhängige Monooxygenase (de, replaced) Cytochrom P-450 (de, replaced) |
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