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Steroid 17-alpha-Hydroxylase

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Hierarchy:	Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Hemeproteins ∟ Cytochromes ∟ Cytochrome P-450 Enzyme System ∟ Steroid Hydroxylases ∟ Steroid 17-alpha-Hydroxylase 10 coordinate concepts 1 subordinate concept ∟ D013254Q000172* ∟ 25-Hydroxyvitamin D3 1-alpha-Hydroxylase \| ∟ Aldosterone Synthase \| ∟ Aromatase \| ∟ Cholesterol 7-alpha-Hydroxylase \| ∟ Cholesterol Side-Chain Cleavage Enzyme \| ∟ Cytochrome P-450 CYP27A1 \| ∟ Steroid 11-beta-Hydroxylase \| ∟ Steroid 12-alpha-Hydroxylase \| ∟ Steroid 16-alpha-Hydroxylase \| ∟ Steroid 21-Hydroxylase Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Cytochromes ∟ Cytochrome P-450 Enzyme System ∟ Steroid Hydroxylases ∟ Steroid 17-alpha-Hydroxylase 10 coordinate concepts 1 subordinate concept ∟ D013254Q000172* ∟ 25-Hydroxyvitamin D3 1-alpha-Hydroxylase \| ∟ Aldosterone Synthase \| ∟ Aromatase \| ∟ Cholesterol 7-alpha-Hydroxylase \| ∟ Cholesterol Side-Chain Cleavage Enzyme \| ∟ Cytochrome P-450 CYP27A1 \| ∟ Steroid 11-beta-Hydroxylase \| ∟ Steroid 12-alpha-Hydroxylase \| ∟ Steroid 16-alpha-Hydroxylase \| ∟ Steroid 21-Hydroxylase Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Enzymes ∟ Oxidoreductases ∟ Oxygenases ∟ Mixed Function Oxygenases ∟ Cytochrome P-450 Enzyme System ∟ Steroid Hydroxylases ∟ Steroid 17-alpha-Hydroxylase 10 coordinate concepts 1 subordinate concept ∟ D013254Q000172* ∟ 25-Hydroxyvitamin D3 1-alpha-Hydroxylase \| ∟ Aldosterone Synthase \| ∟ Aromatase \| ∟ Cholesterol 7-alpha-Hydroxylase \| ∟ Cholesterol Side-Chain Cleavage Enzyme \| ∟ Cytochrome P-450 CYP27A1 \| ∟ Steroid 11-beta-Hydroxylase \| ∟ Steroid 12-alpha-Hydroxylase \| ∟ Steroid 16-alpha-Hydroxylase \| ∟ Steroid 21-Hydroxylase Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Enzymes ∟ Oxidoreductases ∟ Oxygenases ∟ Mixed Function Oxygenases ∟ Steroid Hydroxylases ∟ Steroid 17-alpha-Hydroxylase 10 coordinate concepts 1 subordinate concept ∟ D013254Q000172* ∟ 25-Hydroxyvitamin D3 1-alpha-Hydroxylase \| ∟ Aldosterone Synthase \| ∟ Aromatase \| ∟ Cholesterol 7-alpha-Hydroxylase \| ∟ Cholesterol Side-Chain Cleavage Enzyme \| ∟ Cytochrome P-450 CYP27A1 \| ∟ Steroid 11-beta-Hydroxylase \| ∟ Steroid 12-alpha-Hydroxylase \| ∟ Steroid 16-alpha-Hydroxylase \| ∟ Steroid 21-Hydroxylase X
Broader terms:	Medical Subject Headings (MeSH) ∟ Amino Acids, Peptides, and Proteins ∟ Proteins ∟ Hemeproteins ∟ Cytochromes ∟ Cytochrome P-450 Enzyme System ∟ Steroid Hydroxylases ∟ Steroid 17-alpha-Hydroxylase Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Cytochromes ∟ Cytochrome P-450 Enzyme System ∟ Steroid Hydroxylases ∟ Steroid 17-alpha-Hydroxylase Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Enzymes ∟ Oxidoreductases ∟ Oxygenases ∟ Mixed Function Oxygenases ∟ Cytochrome P-450 Enzyme System ∟ Steroid Hydroxylases ∟ Steroid 17-alpha-Hydroxylase Medical Subject Headings (MeSH) ∟ Enzymes and Coenzymes ∟ Enzymes ∟ Oxidoreductases ∟ Oxygenases ∟ Mixed Function Oxygenases ∟ Steroid Hydroxylases ∟ Steroid 17-alpha-Hydroxylase Steroid Hydroxylases > Cytochrome P-450 Enzyme System > Cytochromes > Hemeproteins > Proteins > Amino Acids, Peptides, and Proteins > Medical Subject Headings (MeSH) Steroid Hydroxylases > Cytochrome P-450 Enzyme System > Cytochromes > Enzymes and Coenzymes > Medical Subject Headings (MeSH) Steroid Hydroxylases > Cytochrome P-450 Enzyme System > Mixed Function Oxygenases > Oxygenases > Oxidoreductases > Enzymes > Enzymes and Coenzymes > Medical Subject Headings (MeSH) Steroid Hydroxylases > Mixed Function Oxygenases > Oxygenases > Oxidoreductases > Enzymes > Enzymes and Coenzymes > Medical Subject Headings (MeSH) X
Narrower terms:	D013254Q000172* X
History note:	Steroid Hydroxylases (1973-1977)X
historyNote*:	2003 (1978) X
publicMeSHNote*:	2003; see STEROID 17 ALPHA-MONOOXYGENASE 1997-2002, see STEROID 17-HYDROXYLASE 1991-1996, see STEROID HYDROXYLASES 1990; for STEROID-17-HYDROXYLASE see STEROID HYDROXYLASES 1978-1989; for 17,20-LYASE see 17 ALPHA-HYDROXYPROGESTERONE ALDOLASE 1996-1997 X
Scope note:	A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation. X
activeMeSHYear*:	2005 \| 2006 \| 2007X
dateCreated*:	1977-04-15X
dateEstablished*:	1991-01-01X
dateRevised*:	2004-07-07X
recordAuthorizer*:	sjnX
recordMaintainer*:	ssbX
recordOriginator*:	RLSX
Related term:	Adrenal Hyperplasia, Congenital X
Type:	Concept X
Coordinate terms:	25-Hydroxyvitamin D3 1-alpha-Hydroxylase \| Aldosterone Synthase \| Aromatase \| Cholesterol 7-alpha-Hydroxylase \| Cholesterol Side-Chain Cleavage Enzyme \| Cytochrome P-450 CYP27A1 \| Steroid 11-beta-Hydroxylase \| Steroid 12-alpha-Hydroxylase \| Steroid 16-alpha-Hydroxylase \| Steroid 21-Hydroxylase X
URI:	X
Labels and equivalent concepts:	Steroidi-17-alfa-hydroksylaasi (fi) Steroid 17-Monooxygenase (en, replaced) Steroid-17-Hydroxylase (en, replaced) Steroid 17-Hydroxylase (en, replaced) Steroid 17 alpha-Monooxygenase (en, replaced) P450(c17) (en, replaced) Steroid 17 alpha-Hydroxylase (en, replaced) Hydroxyprogesterone Aldolase (en, replaced) Cytochrome P450(17 alpha) (en, replaced) 17 alpha-Hydroxylase (en, replaced) Cytochrome P-450(17 alpha) (en, replaced) Cytochrome P-450(17-alpha) (en, replaced) CYP17 (en, replaced) 17,20-Lyase (en, replaced) 17 alpha-Hydroxylase Cytochrome P-450 (en, replaced) 17,20-Desmolase (en, replaced) Esteroide 17-alfa-Hidroxilasa (es) 17-υδροξυλάση στεροειδών (el) Steroid-17-alpha-Hydroxylase (de) steroid-17-alfa-hydroxylasa (cs) 17 alfa-Hidroxilasa (es, replaced) 17,20-Liasa (es, replaced) Esteroide 17-Monooxigenasa (es, replaced) P450(c17) (es, replaced) Esteroide 17-Hidroxilasa (es, replaced) Esteroide 17 alfamonooxigenasa (es, replaced) Citocromo P-450(17 alfa) (es, replaced) CYP17 (es, replaced) Steroid-17-Alpha-Monooxygenase (de, replaced) Steroid-17-Hydroxylase (de, replaced) P450(c17) (de, replaced) Cytochrom-P-450(17-alpha) (de, replaced) 17,20-Lyase (de, replaced) CYP17 (de, replaced) Steroid-17-Monooxygenase (de, replaced) 17-alpha-Hydroxylase (de, replaced) X
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